okfn / opentrials-clinicaltrailsgov-data

Clinical trial data from clinicaltrials.gov


opentrials-clinicaltrailsgov-data

This is a scraper that runs on Morph. To get started see the documentation.

Documents

Configuration

Environment variables to configure the scraper:

  • DATE_FROM

Get trials with last updated mark => this date.

  • DATE_TO

Get trials with last updated mark <= this date.

  • DOWNLOAD_DELAY

Requests we're making to clinicaltrials.gov interval.

Workflow

We need to download around 200 000 pages and we want to be polite to the source webserver:

  • 1s delay -> 60 hours
  • 0.5s delay -> 30 hours (more than morph.io can do for us)
  • etc

So we can scrape manually by years then pull updates for the last year automatically:

  • 1 year (60 000 pages) + 1s delay -> 32 hours
  • 1 year (60 000 pages) + 0.5s delay -> 16 hours
  • 1 year (60 000 pages) + 0.25s delay -> 8 hours
  • etc

Proposed settings for the scraping some year:

DATE_FROM='2010-01-01' DATE_TO='2010-12-31' DOWNLOAD_DELAY='0.25'

Proposed settings for the database updating:

DATE_FROM='2015-10-01' DATE_TO='2015-12-31' DOWNLOAD_DELAY='0.5'

Legal notes

Source of all data scraped by this scraper: clinicaltrials.gov.

ClinicalTrials.gov data are available to all requesters, both within and outside the United States, at no charge.

Terms and conditions

Last run completed successfully .

Console output of last run

Injecting configuration and compiling...  -----> Python app detected -----> Installing python-2.7.9  $ pip install -r requirements.txt  Obtaining scraperwiki from git+http://github.com/openaustralia/scraperwiki-python.git@morph_defaults#egg=scraperwiki (from -r requirements.txt (line 1))  Cloning http://github.com/openaustralia/scraperwiki-python.git (to morph_defaults) to ./.heroku/src/scraperwiki  Collecting scrapy (from -r requirements.txt (line 2))  Downloading Scrapy-1.2.2-py2.py3-none-any.whl (295kB)  Collecting xmltodict (from -r requirements.txt (line 3))  Downloading xmltodict-0.10.2.tar.gz  Collecting ipython (from -r requirements.txt (line 4))  Downloading ipython-5.1.0-py2-none-any.whl (747kB)  Collecting nose (from -r requirements.txt (line 5))  Downloading nose-1.3.7-py2-none-any.whl (154kB)  Collecting dumptruck>=0.1.2 (from scraperwiki->-r requirements.txt (line 1))  Downloading dumptruck-0.1.6.tar.gz  Collecting requests (from scraperwiki->-r requirements.txt (line 1))  Downloading requests-2.12.3-py2.py3-none-any.whl (575kB)  Collecting lxml (from scrapy->-r requirements.txt (line 2))  Downloading lxml-3.6.4-cp27-cp27m-manylinux1_x86_64.whl (4.2MB)  Collecting w3lib>=1.15.0 (from scrapy->-r requirements.txt (line 2))  Downloading w3lib-1.16.0-py2.py3-none-any.whl  Collecting PyDispatcher>=2.0.5 (from scrapy->-r requirements.txt (line 2))  Downloading PyDispatcher-2.0.5.tar.gz  Collecting parsel>=0.9.3 (from scrapy->-r requirements.txt (line 2))  Downloading parsel-1.1.0-py2.py3-none-any.whl  Collecting pyOpenSSL (from scrapy->-r requirements.txt (line 2))  Downloading pyOpenSSL-16.2.0-py2.py3-none-any.whl (43kB)  Collecting queuelib (from scrapy->-r requirements.txt (line 2))  Downloading queuelib-1.4.2-py2.py3-none-any.whl  Collecting six>=1.5.2 (from scrapy->-r requirements.txt (line 2))  Downloading six-1.10.0-py2.py3-none-any.whl  Collecting cssselect>=0.9 (from scrapy->-r requirements.txt (line 2))  Downloading cssselect-1.0.0-py2.py3-none-any.whl  Collecting service-identity (from scrapy->-r requirements.txt (line 2))  Downloading service_identity-16.0.0-py2.py3-none-any.whl  Collecting Twisted>=10.0.0 (from scrapy->-r requirements.txt (line 2))  Downloading Twisted-16.6.0.tar.bz2 (3.0MB)  Collecting decorator (from ipython->-r requirements.txt (line 4))  Downloading decorator-4.0.10-py2.py3-none-any.whl  Collecting pickleshare (from ipython->-r requirements.txt (line 4))  Downloading pickleshare-0.7.4-py2.py3-none-any.whl  Collecting backports.shutil-get-terminal-size; python_version == "2.7" (from ipython->-r requirements.txt (line 4))  Downloading backports.shutil_get_terminal_size-1.0.0-py2.py3-none-any.whl  Collecting pygments (from ipython->-r requirements.txt (line 4))  Downloading Pygments-2.1.3-py2.py3-none-any.whl (755kB)  Collecting pexpect; sys_platform != "win32" (from ipython->-r requirements.txt (line 4))  Downloading pexpect-4.2.1-py2.py3-none-any.whl (55kB)  Collecting pathlib2; python_version == "2.7" or python_version == "3.3" (from ipython->-r requirements.txt (line 4))  Downloading pathlib2-2.1.0-py2.py3-none-any.whl  Collecting simplegeneric>0.8 (from ipython->-r requirements.txt (line 4))  Downloading simplegeneric-0.8.1.zip  Collecting prompt-toolkit<2.0.0,>=1.0.3 (from ipython->-r requirements.txt (line 4))  Downloading prompt_toolkit-1.0.9-py2-none-any.whl (241kB)  Collecting traitlets>=4.2 (from ipython->-r requirements.txt (line 4))  Downloading traitlets-4.3.1-py2.py3-none-any.whl (74kB)  Collecting cryptography>=1.3.4 (from pyOpenSSL->scrapy->-r requirements.txt (line 2))  Downloading cryptography-1.6.tar.gz (410kB)  Collecting pyasn1 (from service-identity->scrapy->-r requirements.txt (line 2))  Downloading pyasn1-0.1.9-py2.py3-none-any.whl  Collecting pyasn1-modules (from service-identity->scrapy->-r requirements.txt (line 2))  Downloading pyasn1_modules-0.0.8-py2.py3-none-any.whl  Collecting attrs (from service-identity->scrapy->-r requirements.txt (line 2))  Downloading attrs-16.3.0-py2.py3-none-any.whl  Collecting zope.interface>=3.6.0 (from Twisted>=10.0.0->scrapy->-r requirements.txt (line 2))  Downloading zope.interface-4.3.2.tar.gz (143kB)  Collecting constantly>=15.1 (from Twisted>=10.0.0->scrapy->-r requirements.txt (line 2))  Downloading constantly-15.1.0-py2.py3-none-any.whl  Collecting incremental>=16.10.1 (from Twisted>=10.0.0->scrapy->-r requirements.txt (line 2))  Downloading incremental-16.10.1-py2.py3-none-any.whl  Collecting ptyprocess>=0.5 (from pexpect; sys_platform != "win32"->ipython->-r requirements.txt (line 4))  Downloading ptyprocess-0.5.1-py2.py3-none-any.whl  Collecting wcwidth (from prompt-toolkit<2.0.0,>=1.0.3->ipython->-r requirements.txt (line 4))  Downloading wcwidth-0.1.7-py2.py3-none-any.whl  Collecting enum34; python_version == "2.7" (from traitlets>=4.2->ipython->-r requirements.txt (line 4))  Downloading enum34-1.1.6-py2-none-any.whl  Collecting ipython-genutils (from traitlets>=4.2->ipython->-r requirements.txt (line 4))  Downloading ipython_genutils-0.1.0-py2.py3-none-any.whl  Collecting idna>=2.0 (from cryptography>=1.3.4->pyOpenSSL->scrapy->-r requirements.txt (line 2))  Downloading idna-2.1-py2.py3-none-any.whl (54kB)  Collecting ipaddress (from cryptography>=1.3.4->pyOpenSSL->scrapy->-r requirements.txt (line 2))  Downloading ipaddress-1.0.17-py2-none-any.whl  Collecting cffi>=1.4.1 (from cryptography>=1.3.4->pyOpenSSL->scrapy->-r requirements.txt (line 2))  Downloading cffi-1.9.1-cp27-cp27m-manylinux1_x86_64.whl (389kB)  Collecting pycparser (from cffi>=1.4.1->cryptography>=1.3.4->pyOpenSSL->scrapy->-r requirements.txt (line 2))  Downloading pycparser-2.17.tar.gz (231kB)  Installing collected packages: dumptruck, requests, scraperwiki, lxml, six, w3lib, PyDispatcher, cssselect, parsel, idna, pyasn1, enum34, ipaddress, pycparser, cffi, cryptography, pyOpenSSL, queuelib, pyasn1-modules, attrs, service-identity, zope.interface, constantly, incremental, Twisted, scrapy, xmltodict, decorator, pathlib2, pickleshare, backports.shutil-get-terminal-size, pygments, ptyprocess, pexpect, simplegeneric, wcwidth, prompt-toolkit, ipython-genutils, traitlets, ipython, nose  Running setup.py install for dumptruck: started  Running setup.py install for dumptruck: finished with status 'done'  Running setup.py develop for scraperwiki  Running setup.py install for PyDispatcher: started  Running setup.py install for PyDispatcher: finished with status 'done'  Running setup.py install for pycparser: started  Running setup.py install for pycparser: finished with status 'done'  Running setup.py install for cryptography: started  Running setup.py install for cryptography: finished with status 'done'  Running setup.py install for zope.interface: started  Running setup.py install for zope.interface: finished with status 'done'  Running setup.py install for Twisted: started  Running setup.py install for Twisted: finished with status 'done'  Running setup.py install for xmltodict: started  Running setup.py install for xmltodict: finished with status 'done'  Running setup.py install for simplegeneric: started  Running setup.py install for simplegeneric: finished with status 'done'  Successfully installed PyDispatcher-2.0.5 Twisted-16.6.0 attrs-16.3.0 backports.shutil-get-terminal-size-1.0.0 cffi-1.9.1 constantly-15.1.0 cryptography-1.6 cssselect-1.0.0 decorator-4.0.10 dumptruck-0.1.6 enum34-1.1.6 idna-2.1 incremental-16.10.1 ipaddress-1.0.17 ipython-5.1.0 ipython-genutils-0.1.0 lxml-3.6.4 nose-1.3.7 parsel-1.1.0 pathlib2-2.1.0 pexpect-4.2.1 pickleshare-0.7.4 prompt-toolkit-1.0.9 ptyprocess-0.5.1 pyOpenSSL-16.2.0 pyasn1-0.1.9 pyasn1-modules-0.0.8 pycparser-2.17 pygments-2.1.3 queuelib-1.4.2 requests-2.12.3 scraperwiki scrapy-1.2.2 service-identity-16.0.0 simplegeneric-0.8.1 six-1.10.0 traitlets-4.3.1 w3lib-1.16.0 wcwidth-0.1.7 xmltodict-0.10.2 zope.interface-4.3.2   -----> Discovering process types  Procfile declares types -> scraper Injecting scraper and running... 2016-12-10 12:00:59 [scrapy] INFO: Scrapy 1.2.2 started (bot: clinicaltrials) 2016-12-10 12:00:59 [scrapy] INFO: Overridden settings: {'AUTOTHROTTLE_ENABLED': True, 'DOWNLOAD_DELAY': 0.5, 'LOG_LEVEL': 'INFO', 'BOT_NAME': 'clinicaltrials', 'SPIDER_MODULES': ['spiders'], 'NEWSPIDER_MODULE': 'spiders'} 2016-12-10 12:00:59 [scrapy] INFO: Enabled extensions: ['scrapy.extensions.corestats.CoreStats', 'scrapy.extensions.telnet.TelnetConsole', 'scrapy.extensions.throttle.AutoThrottle', 'scrapy.extensions.logstats.LogStats'] 2016-12-10 12:00:59 [scrapy] INFO: Enabled downloader middlewares: ['scrapy.downloadermiddlewares.httpauth.HttpAuthMiddleware', 'scrapy.downloadermiddlewares.downloadtimeout.DownloadTimeoutMiddleware', 'scrapy.downloadermiddlewares.defaultheaders.DefaultHeadersMiddleware', 'scrapy.downloadermiddlewares.useragent.UserAgentMiddleware', 'scrapy.downloadermiddlewares.retry.RetryMiddleware', 'scrapy.downloadermiddlewares.redirect.MetaRefreshMiddleware', 'scrapy.downloadermiddlewares.httpcompression.HttpCompressionMiddleware', 'scrapy.downloadermiddlewares.redirect.RedirectMiddleware', 'scrapy.downloadermiddlewares.cookies.CookiesMiddleware', 'scrapy.downloadermiddlewares.chunked.ChunkedTransferMiddleware', 'scrapy.downloadermiddlewares.stats.DownloaderStats'] 2016-12-10 12:00:59 [scrapy] INFO: Enabled spider middlewares: ['scrapy.spidermiddlewares.httperror.HttpErrorMiddleware', 'scrapy.spidermiddlewares.offsite.OffsiteMiddleware', 'scrapy.spidermiddlewares.referer.RefererMiddleware', 'scrapy.spidermiddlewares.urllength.UrlLengthMiddleware', 'scrapy.spidermiddlewares.depth.DepthMiddleware'] 2016-12-10 12:00:59 [scrapy] INFO: Enabled item pipelines: ['pipelines.normalize.Normalize', 'pipelines.database.Database', 'pipelines.jsonfile.Jsonfile'] 2016-12-10 12:00:59 [scrapy] INFO: Spider opened 2016-12-10 12:00:59 [scrapy] INFO: Crawled 0 pages (at 0 pages/min), scraped 0 items (at 0 items/min) Error during info_callback Traceback (most recent call last): File "/app/.heroku/python/lib/python2.7/site-packages/twisted/protocols/tls.py", line 415, in dataReceived self._checkHandshakeStatus() File "/app/.heroku/python/lib/python2.7/site-packages/twisted/protocols/tls.py", line 335, in _checkHandshakeStatus self._tlsConnection.do_handshake() File "/app/.heroku/python/lib/python2.7/site-packages/OpenSSL/SSL.py", line 1425, in do_handshake result = _lib.SSL_do_handshake(self._ssl) File "/app/.heroku/python/lib/python2.7/site-packages/OpenSSL/SSL.py", line 917, in wrapper callback(Connection._reverse_mapping[ssl], where, return_code) --- <exception caught here> --- File "/app/.heroku/python/lib/python2.7/site-packages/twisted/internet/_sslverify.py", line 1151, in infoCallback return wrapped(connection, where, ret) File "/app/.heroku/python/lib/python2.7/site-packages/scrapy/core/downloader/tls.py", line 52, in _identityVerifyingInfoCallback verifyHostname(connection, self._hostnameASCII) File "/app/.heroku/python/lib/python2.7/site-packages/service_identity/pyopenssl.py", line 44, in verify_hostname cert_patterns=extract_ids(connection.get_peer_certificate()), File "/app/.heroku/python/lib/python2.7/site-packages/service_identity/pyopenssl.py", line 73, in extract_ids ids.append(DNSPattern(n.getComponent().asOctets())) File "/app/.heroku/python/lib/python2.7/site-packages/service_identity/_common.py", line 156, in __init__ "Invalid DNS pattern {0!r}.".format(pattern) service_identity.exceptions.CertificateError: Invalid DNS pattern '130.14.81.50'. 2016-12-10 12:01:00 [twisted] CRITICAL: Error during info_callback Traceback (most recent call last): File "/app/.heroku/python/lib/python2.7/site-packages/twisted/protocols/tls.py", line 415, in dataReceived self._checkHandshakeStatus() File "/app/.heroku/python/lib/python2.7/site-packages/twisted/protocols/tls.py", line 335, in _checkHandshakeStatus self._tlsConnection.do_handshake() File "/app/.heroku/python/lib/python2.7/site-packages/OpenSSL/SSL.py", line 1425, in do_handshake result = _lib.SSL_do_handshake(self._ssl) File "/app/.heroku/python/lib/python2.7/site-packages/OpenSSL/SSL.py", line 917, in wrapper callback(Connection._reverse_mapping[ssl], where, return_code) --- <exception caught here> --- File "/app/.heroku/python/lib/python2.7/site-packages/twisted/internet/_sslverify.py", line 1151, in infoCallback return wrapped(connection, where, ret) File "/app/.heroku/python/lib/python2.7/site-packages/scrapy/core/downloader/tls.py", line 52, in _identityVerifyingInfoCallback verifyHostname(connection, self._hostnameASCII) File "/app/.heroku/python/lib/python2.7/site-packages/service_identity/pyopenssl.py", line 44, in verify_hostname cert_patterns=extract_ids(connection.get_peer_certificate()), File "/app/.heroku/python/lib/python2.7/site-packages/service_identity/pyopenssl.py", line 73, in extract_ids ids.append(DNSPattern(n.getComponent().asOctets())) File "/app/.heroku/python/lib/python2.7/site-packages/service_identity/_common.py", line 156, in __init__ "Invalid DNS pattern {0!r}.".format(pattern) service_identity.exceptions.CertificateError: Invalid DNS pattern '130.14.81.50'. Error during info_callback Traceback (most recent call last): File "/app/.heroku/python/lib/python2.7/site-packages/twisted/protocols/tls.py", line 415, in dataReceived self._checkHandshakeStatus() File "/app/.heroku/python/lib/python2.7/site-packages/twisted/protocols/tls.py", line 335, in _checkHandshakeStatus self._tlsConnection.do_handshake() File "/app/.heroku/python/lib/python2.7/site-packages/OpenSSL/SSL.py", line 1425, in do_handshake result = _lib.SSL_do_handshake(self._ssl) File "/app/.heroku/python/lib/python2.7/site-packages/OpenSSL/SSL.py", line 917, in wrapper callback(Connection._reverse_mapping[ssl], where, return_code) --- <exception caught here> --- File "/app/.heroku/python/lib/python2.7/site-packages/twisted/internet/_sslverify.py", line 1151, in infoCallback return wrapped(connection, where, ret) File "/app/.heroku/python/lib/python2.7/site-packages/scrapy/core/downloader/tls.py", line 52, in _identityVerifyingInfoCallback verifyHostname(connection, self._hostnameASCII) File "/app/.heroku/python/lib/python2.7/site-packages/service_identity/pyopenssl.py", line 44, in verify_hostname cert_patterns=extract_ids(connection.get_peer_certificate()), File "/app/.heroku/python/lib/python2.7/site-packages/service_identity/pyopenssl.py", line 73, in extract_ids ids.append(DNSPattern(n.getComponent().asOctets())) File "/app/.heroku/python/lib/python2.7/site-packages/service_identity/_common.py", line 156, in __init__ "Invalid DNS pattern {0!r}.".format(pattern) service_identity.exceptions.CertificateError: Invalid DNS pattern '130.14.81.50'. 2016-12-10 12:01:07 [twisted] CRITICAL: Error during info_callback Traceback (most recent call last): File "/app/.heroku/python/lib/python2.7/site-packages/twisted/protocols/tls.py", line 415, in dataReceived self._checkHandshakeStatus() File "/app/.heroku/python/lib/python2.7/site-packages/twisted/protocols/tls.py", line 335, in _checkHandshakeStatus self._tlsConnection.do_handshake() File "/app/.heroku/python/lib/python2.7/site-packages/OpenSSL/SSL.py", line 1425, in do_handshake result = _lib.SSL_do_handshake(self._ssl) File "/app/.heroku/python/lib/python2.7/site-packages/OpenSSL/SSL.py", line 917, in wrapper callback(Connection._reverse_mapping[ssl], where, return_code) --- <exception caught here> --- File "/app/.heroku/python/lib/python2.7/site-packages/twisted/internet/_sslverify.py", line 1151, in infoCallback return wrapped(connection, where, ret) File "/app/.heroku/python/lib/python2.7/site-packages/scrapy/core/downloader/tls.py", line 52, in _identityVerifyingInfoCallback verifyHostname(connection, self._hostnameASCII) File "/app/.heroku/python/lib/python2.7/site-packages/service_identity/pyopenssl.py", line 44, in verify_hostname cert_patterns=extract_ids(connection.get_peer_certificate()), File "/app/.heroku/python/lib/python2.7/site-packages/service_identity/pyopenssl.py", line 73, in extract_ids ids.append(DNSPattern(n.getComponent().asOctets())) File "/app/.heroku/python/lib/python2.7/site-packages/service_identity/_common.py", line 156, in __init__ "Invalid DNS pattern {0!r}.".format(pattern) service_identity.exceptions.CertificateError: Invalid DNS pattern '130.14.81.50'. Error during info_callback Traceback (most recent call last): File "/app/.heroku/python/lib/python2.7/site-packages/twisted/protocols/tls.py", line 415, in dataReceived self._checkHandshakeStatus() File "/app/.heroku/python/lib/python2.7/site-packages/twisted/protocols/tls.py", line 335, in _checkHandshakeStatus self._tlsConnection.do_handshake() File "/app/.heroku/python/lib/python2.7/site-packages/OpenSSL/SSL.py", line 1425, in do_handshake result = _lib.SSL_do_handshake(self._ssl) File "/app/.heroku/python/lib/python2.7/site-packages/OpenSSL/SSL.py", line 917, in wrapper callback(Connection._reverse_mapping[ssl], where, return_code) --- <exception caught here> --- File "/app/.heroku/python/lib/python2.7/site-packages/twisted/internet/_sslverify.py", line 1151, in infoCallback return wrapped(connection, where, ret) File "/app/.heroku/python/lib/python2.7/site-packages/scrapy/core/downloader/tls.py", line 52, in _identityVerifyingInfoCallback verifyHostname(connection, self._hostnameASCII) File "/app/.heroku/python/lib/python2.7/site-packages/service_identity/pyopenssl.py", line 44, in verify_hostname cert_patterns=extract_ids(connection.get_peer_certificate()), File "/app/.heroku/python/lib/python2.7/site-packages/service_identity/pyopenssl.py", line 73, in extract_ids ids.append(DNSPattern(n.getComponent().asOctets())) File "/app/.heroku/python/lib/python2.7/site-packages/service_identity/_common.py", line 156, in __init__ "Invalid DNS pattern {0!r}.".format(pattern) service_identity.exceptions.CertificateError: Invalid DNS pattern '130.14.81.50'. 2016-12-10 12:01:15 [twisted] CRITICAL: Error during info_callback Traceback (most recent call last): File "/app/.heroku/python/lib/python2.7/site-packages/twisted/protocols/tls.py", line 415, in dataReceived self._checkHandshakeStatus() File "/app/.heroku/python/lib/python2.7/site-packages/twisted/protocols/tls.py", line 335, in _checkHandshakeStatus self._tlsConnection.do_handshake() File "/app/.heroku/python/lib/python2.7/site-packages/OpenSSL/SSL.py", line 1425, in do_handshake result = _lib.SSL_do_handshake(self._ssl) File "/app/.heroku/python/lib/python2.7/site-packages/OpenSSL/SSL.py", line 917, in wrapper callback(Connection._reverse_mapping[ssl], where, return_code) --- <exception caught here> --- File "/app/.heroku/python/lib/python2.7/site-packages/twisted/internet/_sslverify.py", line 1151, in infoCallback return wrapped(connection, where, ret) File "/app/.heroku/python/lib/python2.7/site-packages/scrapy/core/downloader/tls.py", line 52, in _identityVerifyingInfoCallback verifyHostname(connection, self._hostnameASCII) File "/app/.heroku/python/lib/python2.7/site-packages/service_identity/pyopenssl.py", line 44, in verify_hostname cert_patterns=extract_ids(connection.get_peer_certificate()), File "/app/.heroku/python/lib/python2.7/site-packages/service_identity/pyopenssl.py", line 73, in extract_ids ids.append(DNSPattern(n.getComponent().asOctets())) File "/app/.heroku/python/lib/python2.7/site-packages/service_identity/_common.py", line 156, in __init__ "Invalid DNS pattern {0!r}.".format(pattern) service_identity.exceptions.CertificateError: Invalid DNS pattern '130.14.81.50'. 2016-12-10 12:01:15 [scrapy] ERROR: Error downloading <GET https://www.clinicaltrials.gov/ct2/results?lup_s=10%2F01%2F2015&lup_e=12%2F31%2F2015>: [<twisted.python.failure.Failure service_identity.exceptions.CertificateError: Invalid DNS pattern '130.14.81.50'.>] 2016-12-10 12:01:15 [scrapy] INFO: Closing spider (finished) 2016-12-10 12:01:15 [scrapy] INFO: Dumping Scrapy stats: {'downloader/exception_count': 3, 'downloader/exception_type_count/twisted.web._newclient.ResponseNeverReceived': 3, 'downloader/request_bytes': 819, 'downloader/request_count': 3, 'downloader/request_method_count/GET': 3, 'finish_reason': 'finished', 'finish_time': datetime.datetime(2016, 12, 10, 12, 1, 15, 249097), 'log_count/CRITICAL': 3, 'log_count/ERROR': 1, 'log_count/INFO': 7, 'scheduler/dequeued': 3, 'scheduler/dequeued/memory': 3, 'scheduler/enqueued': 3, 'scheduler/enqueued/memory': 3, 'start_time': datetime.datetime(2016, 12, 10, 12, 0, 59, 540170)} 2016-12-10 12:01:15 [scrapy] INFO: Spider closed (finished)

Data

Downloaded 4469 times by idwtsiwgh biomac MikeRalphson roll henare

To download data sign in with GitHub

Download table (as CSV) Download SQLite database (2.45 GB) Use the API

rows 10 / 205747

source has_expanded_access study_type detailed_description lastchanged_date overall_officials firstreceived_date start_date study_design phase sponsors eligibility link_text locations oversight_info conditions brief_summary url location_countries overall_status verification_date nct_id interventions primary_outcomes brief_title official_title org_study_id keywords download_date condition_browse secondary_outcomes intervention_browse secondary_ids overall_contact overall_contact_backup enrollment_anticipated references completion_date_anticipated links nct_aliases results_references removed_countries enrollment_actual number_of_arms completion_date_actual primary_completion_date_actual arm_groups responsible_party is_fda_regulated number_of_groups is_section_801 primary_completion_date_anticipated acronym biospec_retention biospec_descr why_stopped clinical_results target_duration other_outcomes
Northwestern Health Sciences University
No
Interventional
Low back pain remains an important public health problem with serious socioeconomic consequences. Despite the considerable amount of research that has been preformed, there is still a dire need for randomized clinical tiles of high methodological quality. The broad, long-term objective of this interdisciplinary research is to identify effective therapies for low back pain sufferers and increased understanding of this important condition. Building upon the principal investigators' previous collaborative research, this randomized observer-blinded clinical trial will compare the following treatment for patients with nonacute low back pain: 1. chiropractic spinal manipulation 2. rehabilitative exercise 3. self care education Theprimary aim is to examine the relative efficacy of the three interventions in terms of patient rated outcomes in the short-term (after 12 weeks) and the long-term (after 52 weeks) for nonacute low back pain. Secondary aims include: 1. To examine the short and long-term relative cost effectiveness and cost utility of the three treatments. 2. To assess if there are clinically important differences between pre-specified subgroups of low back pain patients. Subgroups are based on duration and current episode and radiating leg pain. 3. To evaluate if there treatment group differences in objective lumbar spine function (range of motion, strength and endurance) after 12 weeks of treatment and if changes in lumbar function are associated with changes in patient rated short and long-term outcomes. 4. To identify if baseline demographic or clinical variables can predict short or long-term outcome. 5. To describe patients' interpretations and perceptions of outcome measures used in clinical trials.
December 22, 2005
[{"last_name": "Gert Bronfort, DC, PhD", "role": "Principal Investigator", "affiliation": "Northwestern Health Sciences University"}]
December 21, 2005
January 2001
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind, Primary Purpose: Treatment
Phase 2
[{"lead_sponsor": {"agency": "Northwestern Health Sciences University", "agency_class": "Other"}}, {"collaborator": {"agency": "HRSA/Maternal and Child Health Bureau", "agency_class": "U.S. Fed"}}, {"collaborator": {"agency": "Berman Center for Outcomes and Clinical Research", "agency_class": "Other"}}]
{"criteria": {"textblock": "Inclusion Criteria: patients are 18-65 years of age; Qu\u00e9bec task force classification\n 1,2,3 and 4 (this includes patients with back pain, stiffness or tenderness, with or\n without musculoskeletal signs and neurological signs); primary complaint of back pain,\n with current episode greater than or equal to six weeks duration(this includes subacute\n and chronic patients for whom the study treatments are an option)\n\n Exclusion Criteria:\n\n - previous lumbar spine surgery; back pain referred from local joint lesions of the\n lower extremities or from visceral diseases; progressive neurological deficits due to\n nerve root or spinal cord compression; aortic and peripheral vascular disease;\n existing cardiac disease requiring medical treatment; blood clotting disorders;\n diffuse idiopathic hyperostosis; infectious and noninfectious inflammatory or\n destructive tissue changes of the lumbar spine; presence of significant infectious\n disease, or other severe debilitating health problems; substance abuse; ongoing\n treatment for back pain by other health care providers; pregnant or nursing women;\n pain score of less than 30 percentage points; pending our current litigation"}, "gender": "Both", "minimum_age": "18 Years", "maximum_age": "65 Years", "healthy_volunteers": "Accepts Healthy Volunteers"}
Link to the current ClinicalTrials.gov record.
[{"facility": {"name": "Northwestern Health Sciences University", "address": {"city": "Bloomington", "state": "Minnesota", "zip": "55431", "country": "United States"}}}]
{"authority": "United States: Institutional Review Board"}
["Low Back Pain"]
The broad, long term objective of this interdisciplinary research is to identify effective therapies for low back pain sufferers and to increase our understanding of this important condition. The primary aim is to examine the relative efficacy of chiropractic spinal manipulation, rehabilitative exercise, and self-care education in terms of patient-rated outcomes in the short and long term for non-acute low back pain.
["United States"]
Completed
December 2005
NCT00269347
[{"intervention_type": "Procedure", "intervention_name": "Chiropractic Spinal Manipulation"}, {"intervention_type": "Procedure", "intervention_name": "Exercise"}, {"intervention_type": "Behavioral", "intervention_name": "Self-care"}]
[{"measure": "Pain (Visual Analog Scale) at baseline, weeks 4,12,26,52"}]
Manipulation, Exercise, and Self-Care for Low Back Pain
Manipulation, Exercise, and Self-Care for Low Back Pain
R18HP10009
["Chiropractic", "Manual Therapy", "Exercise", "Randomized", "Clinical Trial", "Back Pain"]
ClinicalTrials.gov processed this data on October 13, 2015
{"mesh_term": ["Back Pain", "Low Back Pain"]}
[{"measure": "Disability (Modified Roland Scale) at baseline, weeks 4,12,26,52"}, {"measure": "General Health (SF-36) at baseline, weeks 4,12,26,52"}, {"measure": "Improvement (7 point scale) at baseline, weeks 4,12,26,52"}, {"measure": "Disability (NHIS) at baseline, weeks 4,12,26,52"}, {"measure": "Bothersomeness (7 point scale) at baseline, weeks 4,12,26,52"}, {"measure": "Frequency (7 point scale) at baseline, weeks 4,12,26,52"}, {"measure": "Satisfaction (5 point scale) at baseline, weeks 4,12,26,52"}, {"measure": "Depression (CES-D) at baseline, weeks 4,12,26,52"}, {"measure": "Medication use at baseline, weeks 4,12,26,52"}, {"measure": "Fear-avoidance (FABQ) at baseline, weeks 4,12,26,52"}, {"measure": "Lumbar range of motion at baseline, weeks 4,12,26,52"}, {"measure": "Lumbar strength and endurance at baseline, weeks 4,12,26,52"}, {"measure": "Health care costs and utilization at baseline, weeks 4,12,26,52"}]
Sheba Medical Center
No
Observational
December 22, 2005
[{"last_name": "Joseph Zohar, MD", "role": "Principal Investigator", "affiliation": "Tel Aviv University"}]
December 22, 2005
Observational Model: Defined Population, Time Perspective: Longitudinal
N/A
[{"lead_sponsor": {"agency": "Sheba Medical Center", "agency_class": "Other"}}]
{"criteria": {"textblock": "Inclusion Criteria:\n\n - People were in the earthquake area while it occured\n\n Exclusion Criteria:\n\n - People were not in the earthquake area while it occured"}, "gender": "Both", "minimum_age": "N/A", "maximum_age": "N/A"}
Link to the current ClinicalTrials.gov record.
{"authority": "Israel: Israeli Health Ministry Pharmaceutical Administration"}
["Post-Traumatic Stress Disorder"]
Assessing the prevalence and natural course of PTSD after the 1999 Turkish earthquake
Active, not recruiting
December 2005
NCT00269451
Assessing PTSD After Earthquake in Turkey
PTSD Turkey
ClinicalTrials.gov processed this data on October 13, 2015
{"mesh_term": ["Stress Disorders, Post-Traumatic", "Stress Disorders, Traumatic"]}
Sanofi
Interventional
December 27, 2005
December 22, 2005
December 2000
Allocation: Randomized, Endpoint Classification: Safety Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment
Phase 3
[{"lead_sponsor": {"agency": "Sanofi", "agency_class": "Industry"}}, {"collaborator": {"agency": "Takeda", "agency_class": "Industry"}}]
{"criteria": {"textblock": "Inclusion Criteria:\n\n - Females between 5 and 7.5 years and male between 5 and 8.5 years of age with normal\n heights, a history of mild persistent asthma for at least 3 months prior to visit 1,\n a forced expiratory volume in one second (FEV1) of \u00b380% of predicted following at\n least a 4-hour albuterol withhold, and treated with non-corticosteroid asthma\n medications on an as-needed or daily basis, or with low doses of inhaled\n corticosteroids (ICSs) for at least one month prior to Visit 1. Subjects were to be\n no greater than Stage 1 in the Tanner classification of sexual maturity, and they had\n to be able to demonstrate effective use of the MDI devices and perform reproducible\n pulmonary function test.\n\n Exclusion Criteria:\n\n - Subjects with a history of life-threatening asthma, severe respiratory impairment,\n history of abnormal growth, concurrent disease or condition which may substantially\n affect growth, previous requirement for daily or alternate day oral corticosteroids\n (OCS) treatment for \u00b360 days within the 2 years of Visit 3 and/or any use of OCS\n within 30 days prior to Visit 1 or during the run-in period, previous treatment with\n moderate or high doses of inhaled corticosteroid during the 30 days prior to Visit 1"}, "gender": "Both", "minimum_age": "5 Years", "maximum_age": "102 Months", "healthy_volunteers": "No"}
Link to the current ClinicalTrials.gov record.
{"authority": "United States: Food and Drug Administration"}
["Asthma"]
The primary objective is to determine if CIC 50 mg/day or 200 mg/day (ex-valve) administered once daily in the morning is non-inferior to placebo with respect to growth velocity in children with mild persistent asthma following a 12-month treatment period The secondary objective is to investigate changes in growth in terms of bone age (wrist X-ray), and maintenance of asthma control and safety with ciclesonide
Completed
December 2005
NCT00270348
[{"intervention_type": "Drug", "intervention_name": "ciclesonide"}]
[{"measure": "Subject\u2019s height measured w. standard stadiometry techniques. 4 acceptable serial measurements taken at each visit on same equipment by a qualified technician.Median of 4 measurements used the subject\u2019s stadiometer height data"}]
Effects of Ciclesonide MDI 50mg/Day and 200mg/Day (Ex-Valve) Once-Daily on Growth in Children With Mild Persistent Asthma
A Phase III, Multicenter, Double-Blind, Placebo Controlled, Non-Inferiority Study Assessing the Effects of Ciclesonide Metered Dose Inhaler 50 Mg/Day and 200 Mg/Day (Ex-Valve) Administered Once Daily on Growth in Children With Mild Persistent Asthma
LTS6159
["Asthma", "Safety", "Pediatrics"]
ClinicalTrials.gov processed this data on October 13, 2015
{"mesh_term": "Asthma"}
[{"measure": "Blinded assessment of bone age according to Greulich and Pyle radiographic atlas with wrist X-rays. Subjects monitored for AEs and any events occurring during study. Pulmonary function tests performed to measure FEV1 in liters and % of predicted FEV1"}]
{"mesh_term": "Ciclesonide"}
["XRP1526B - 343"]
University of Maryland
No
Interventional
Patients presenting with locally advanced squamous cell carcinomas of head and neck (SCCHN) continue to represent a significant therapeutic challenge. The bulk of tumor burden often proves to be overwhelming for conventional radiotherapy. Attempts to improve upon these poor outcomes have led investigators to explore several new strategies, one such being chemoradiation. One of the trials conducted at the University of Maryland with carboplatin and paclitaxel with daily radiation showed 82% CR at the primary site. But the most commonly encountered grade 3 toxicities were mucositis (70%), leukopenia (30%) and 3% grade 4 leukopenia. Amifostine: An organic thiophosphate is radioprotective and has shown to protect experimental animals from lethal doses of radiation. Clinical trials have demonstrated that amifostine can provide protection against the hematological toxicities and mucositis seen with various chemotherapeutic agents. Theoretically, drug interactions between amifostine and chemotherapeutic agents are not likely to occur, due to amifostine¿s rapid clearance from plasma (90% of the drug is cleared within 6 minutes). A promising venue would be the investigation of amifostine¿s role in reducing the toxicities associated with chemoradiation (which is standard of care of treating squamous cell carcinomas of head and neck). Principal objectives of the study: Primary: To evaluate whether the addition of the radioprotector amifostine can reduce the incidence and severity of mucositis and hematological toxicities caused by chemoradiation. Secondary: 1.To determine the toxicities of amifostine given in this setting. 2. To determine the response rate of this regimen in the population.
December 23, 2005
[{"last_name": "Mohan Suntharalingam, MD", "role": "Principal Investigator", "affiliation": "University of Maryland"}]
December 23, 2005
May 2002
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Phase 2
[{"lead_sponsor": {"agency": "University of Maryland", "agency_class": "Other"}}, {"collaborator": {"agency": "MedImmune LLC", "agency_class": "Industry"}}]
{"criteria": {"textblock": "Inclusion Criteria:\n\n 1. Histologically proved locally advanced squamous cell carcinoma of the head and neck\n of all primary sites. The following TNM stages by sites will be eligible.\n\n Oral cavity, Pharynx, Larynx, Nasopharynx, paranasal sinuses: T4 N0-3, A,B,C T3 N1-3\n A,B,C any T, N3 A,B,C Unknown primary: Tx, N3 A,B,C Note: Only clearly unresectable\n T4 N0 lesions are eligible for study provided the reasons for unresectability are due\n to extensive anatomic involvement and are outlined by the surgeon.\n\n 2. Karnofsky performance status of 70% or better at screen and on first day of\n treatment.\n\n 3. Patients with loco-regional recurrences from any site with no prior radiation therapy\n and not amenable for salvage surgery are eligible for study.\n\n 4. No evidence of distant metastatic disease.\n\n 5. No previous radiation therapy\n\n 6. No previous chemotherapy.\n\n 7. Adequate renal & bone marrow function determined by the following laboratory\n parameters.\n\n WBC 3500/ul or higher Platelet count 100.000/ul or higher Hemoglobin 9.0 g/dl or\n higher BUN 25 mg/dl or less, and Screatinine 2.0 mg/dl or less Total bilirubin less\n than 2.0 mg/dl, AST/ALT less than 3 times the ULN Creatinine Clearance 50 cc/min or\n higher\n\n 8. Evidence of measurable disease.\n\n 9. No evidence of concomitant malignancy except for non-melanomatous skin cancer\n (controlled or controllable) or carcinoma in situ of the cervix.\n\n 10. Signed informed consent.\n\n 11. No concomitant life threatening or uncontrolled serious medical illness such as end\n stage congestive heart failure cardiac arrythmia, liver disease and organic brain\n syndrome.\n\n 12. Age 18 years or older.\n\n Exclusion Criteria:\n\n 1. Preexisting clinically significant neuropathy.\n\n 2. Patients currently taking antiarrhythmic medications are excluded.\n\n 3. History of poorly-controlled hypertension, angina, arrhythmias, or a history within\n the past 6 months of myocardial infarction or acute congestive heart failure.\n\n 4. Requirement for concurrent use of pilocarpine.\n\n 5. Treatment with any investigational drugs within 4 weeks of study entry.\n\n 6. Pregnant or lactating females or females of child bearing potential not employing\n adequate contraception."}, "gender": "Both", "minimum_age": "18 Years", "maximum_age": "N/A", "healthy_volunteers": "No"}
Link to the current ClinicalTrials.gov record.
[{"facility": {"name": "University of Maryland", "address": {"city": "Baltimore", "state": "Maryland", "zip": "21201", "country": "United States"}}}]
{"authority": "United States: Food and Drug Administration"}
["Head and Neck Cancer."]
Purpose of this study: There is some evidence that the best treatment for head and neck cancer involves a combination of radiation therapy and chemotherapy. Radiation therapy is a form of cancer treatment using high energy x-rays. Chemotherapy is a form of cancer treatment that uses special medications. This study uses two chemotherapy drugs (Taxol and Carboplatin), which are FDA approved for treating head and neck cancers. This treatment combination has been associated with difficulty, pain, or a burning sensation upon swallowing (called esophagitis), and decrease in blood cells (cells in the blood which fight against infection). The purpose of this study is to investigate whether the addition of another drug, Amifostine, can reduce the side effects of current combination treatment (radiation and chemotherapy which is standard of care). The addition of Amifostine is the investigational part of the study. The research study is also looking at the side effects of Amifostine and cancer's growth response to this combination treatment.
["United States"]
Completed
December 2005
NCT00270790
[{"intervention_type": "Drug", "intervention_name": "Amifostine"}, {"intervention_type": "Drug", "intervention_name": "Carboplatin"}, {"intervention_type": "Drug", "intervention_name": "Taxol"}, {"intervention_type": "Device", "intervention_name": "Radiotherapy"}]
[{"measure": "To evaluate whether the addition of the radioprotector Amifostine can reduce the incidence and severity of mucositis and hematological toxicities caused by chemoradiation."}]
EVALUATION OF AMIFOSTINE FOR MUCOSAL AND HEMOPOETIC PROTECTION AND CARBOPLATIN, TAXOL, RADIOTHERAPY IN THE MANAGEMENT OF PATIENTS WITH HEAD AND NECK CANCER.
A SINGLE SITE EVALUATION OF AMIFOSTINE FOR MUCOSAL AND HEMOPOETIC PROTECTION AND CONCURRENT CARBOPLATIN, TAXOL, RADIOTHERAPY IN THE MANAGEMENT OF PATIENTS WITH ADVANCED LOCOREGIONAL SQUAMOUS CELL CARCINOMAS OF THE HEAD AND NECK.
GCC 0202
["Head and Neck cancer"]
ClinicalTrials.gov processed this data on October 13, 2015
{"mesh_term": "Head and Neck Neoplasms"}
[{"measure": "1.To determine the toxicities of Amifostine given in this setting."}, {"measure": "2. To determine the response rate of this regimen in the population."}]
{"mesh_term": ["Amifostine", "Carboplatin"]}
Ortec International
Interventional
December 28, 2005
December 28, 2005
April 2002
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
N/A
[{"lead_sponsor": {"agency": "Ortec International", "agency_class": "Industry"}}]
{"criteria": {"textblock": "Inclusion Criteria:\n\n - Any race, between 18 and 85 years of age\n\n - Male or female\n\n - Chronic venous insufficiency\n\n - Ulcer size between 2 and 20 sq cm, inclusive\n\n - Ulcer present for at least one month\n\n - ABI >0.7\n\n Exclusion Criteria:\n\n - Decrease in wound size >35% during Screening Phase\n\n - Infection at the ulcer site\n\n - Uncontrolled diabetes mellitus\n\n - Previous treatment with excluded medications"}, "gender": "Both", "minimum_age": "18 Years", "maximum_age": "85 Years", "healthy_volunteers": "No"}
Link to the current ClinicalTrials.gov record.
[{"facility": {"name": "Terry Treadwell, MD", "address": {"city": "Montgomery", "state": "Alabama", "zip": "33134", "country": "United States"}}}]
{"authority": "United States: Food and Drug Administration"}
["Venous Leg Ulcer", "Venous Stasis Ulcer"]
This study was designed to evaluate the clinical benefits and safety of OrCel in the treatment of venous ulcers. OrCel and standard care were compared to standard care alone. Standard care consisted of currently accepted compression therapy. Patients were treated for 12 weeks. Patients with healed ulcers were followed for an additional 12 weeks to assess durability of the healed wound.
["United States"]
Completed
December 2005
NCT00270946
[{"intervention_type": "Device", "intervention_name": "Bilayered Cellular Matrix (OrCel)"}]
[{"measure": "Investigator assessment of wound healing"}]
Evaluation of Bilayered Cellular Matrix (OrCel) for the Treatment of Venous Ulcers
A Pivotal Study to Evaluate the Safety and Efficacy of Cryopreserved Bilayered Cellular Matrix (OrCel) for the Treatment of Venous Ulcers
100-VLU-01-CLN
["Venous leg ulcer", "OrCel", "Compression therapy"]
ClinicalTrials.gov processed this data on October 13, 2015
{"mesh_term": ["Leg Ulcer", "Postphlebitic Syndrome", "Postthrombotic Syndrome", "Ulcer", "Varicose Ulcer"]}
[{"measure": "Planimetric assessment of wound healing"}, {"measure": "Photographic assessment of wound healing"}]
Hillel Yaffe Medical Center
No
Observational
Since alterations in mitochondrial functions in platelets and lymphocytes have been detected in Parkinson's disease we plan to monitor the metabolism a a new molecule (LTG) in the blood samples of Parkinson's disease patients and compare them to controls. We shall use 10 cc of venous blood and analyze serum, white blood cells and platelets. We shall not extract nor use DNA.The main purpose is to develop a marker for Parkinson's disease in venous blood.
December 29, 2005
[{"last_name": "Rivka Inzelberg, MD", "role": "Principal Investigator", "affiliation": "Hillel Yaffe Medical Center"}]
December 29, 2005
May 2005
Primary Purpose: Screening, Time Perspective: Cross-Sectional
N/A
[{"lead_sponsor": {"agency": "Hillel Yaffe Medical Center", "agency_class": "Other"}}, {"collaborator": {"agency": "Technion, Israel Institute of Technology", "agency_class": "Other"}}]
{"criteria": {"textblock": "Inclusion Criteria:\n\n Parkinson's disease Healthy control -\n\n Exclusion Criteria:\n\n None -"}, "gender": "Both", "minimum_age": "18 Years", "maximum_age": "N/A", "healthy_volunteers": "Accepts Healthy Volunteers"}
Link to the current ClinicalTrials.gov record.
[{"facility": {"name": "Hillel Yaffe Medical Center", "address": {"city": "Hadera", "country": "Israel"}}, "status": "Recruiting", "investigator": {"last_name": "Rivka Inzelberg, MD", "role": "Principal Investigator"}}]
{"authority": "Israel: Israeli Health Ministry Pharmaceutical Administration"}
["Parkinson's Disease", "Oxidative Stress"]
The proposed work is based on the detection of a novel molecule for sensitivity to oxidative stress in humans in venous blood
["Israel"]
Recruiting
December 2005
NCT00271141
Multifunctional Substrate for Early Detection of Oxidative Stress Susceptibility and Application to Parkinson's Disease
Multifunctional Substrate for Early Detection of Oxidative Stress Susceptibility and Application to Parkinson's Disease
hy11/2005
["Parkinson's disease", "Oxidative stress", "Marker"]
ClinicalTrials.gov processed this data on October 13, 2015
{"mesh_term": ["Disease Susceptibility", "Parkinson Disease"]}
{"last_name": "Rivka Inzelberg, MD", "phone": "+972-4-6304607", "email": "inzelberg@hy.health.gov.il"}
Hadassah Medical Organization
No
Observational
Backround: Genetic and epigenetic abrasions like loss of hetherozygosity and hypermethylation of gene promoters are common aberration in gliomas. Detection of these aberrations serves as diagnostic and prognostic tool. Examples: 1. oligodendrogliomas patients with combined 1p/19q LOH within the tumor respond better to chemotherapy and have better prognosis, whereas LOH on chromosome 10q is a marker for worse prognosis. 2. GBM patients with hypermethylation of the promoter of methyl-guanine-methyl-transferase (MGMT) in the tumor respond better to alkylating agent and have better prognosis. As sample materials for diagnosis should be easily accessible by a minimally invasive procedure, there has been much interest in the potential use of nucleic acid markers in the blood of patients with cancer. It was demonstrated that LOH as well as hypermethylation could be detected in the plasma/serum of patients with a variety of malignancies, suggesting that circulating tumor-associated DNA in the blood of patients can be a key determinant in predicting genetic and epigenetic abrasions in the tumor. Objectives of the study: Main objective: to find whether genetic abrasions in serum DNA represent the tumor DNA in patients with brain tumor. Is tumor DNA can be detected in the serum of only high grade tumors or also in low grade tumor? Methods: Blood serum and tumor of patients are obtained anonymously, after the patient has signed a consent form, prior to surgery as part of the procedure for tissue collection for the brain tumor bank at Hadassah. Part of the tumor is stained with hematoxylin-and-eosin and Histopathologic diagnosis is performed by a pathologist. DNA is extracted from whole blood, serum and tumor of all patients with low grade or high grade gliomas. In order to determine whether serum DNA represents the tumor DNA, LOH of 1p,19q,10q,17p,13q, 9p as well as methylation status of MGMT promoter will be tested in DNA samples from blood, serum and tumor.
December 13, 2005
[{"last_name": "TALI SIEGAL, MD", "role": "Principal Investigator", "affiliation": "Hadassah Medical Organization"}, {"last_name": "IRIS LAVON, PHD", "role": "Study Director", "affiliation": "Hadassah Medical Organization"}]
December 13, 2005
January 2006
Observational Model: Defined Population, Primary Purpose: Screening, Time Perspective: Longitudinal
N/A
[{"lead_sponsor": {"agency": "Hadassah Medical Organization", "agency_class": "Other"}}]
{"criteria": {"textblock": "Inclusion Criteria:\n\n LOW AND HIGH GRADE GLIOMAS\n\n Exclusion Criteria:\n\n NON GLIAL TUMORS"}, "gender": "Both", "minimum_age": "N/A", "maximum_age": "N/A", "healthy_volunteers": "No"}
Link to the current ClinicalTrials.gov record.
[{"facility": {"name": "Hdassah Medical Organization", "address": {"city": "Jerusalem", "zip": "91120", "country": "Israel"}}, "status": "Not yet recruiting", "contact": {"last_name": "Arik Tzukert, DMD", "phone": "00-972-2-6777572", "email": "lhadas@HADASSAH.ORG.IL"}}]
{"authority": "Israel: Israeli Health Ministry Pharmaceutical Administration"}
["Primary Brain Tumor"]
Numerous studies document the ability of tumors to shed DNA into the blood stream. Circulating DNA can thus be recovered for analyses, representing a surrogate tumor material to test for potential applications in disease diagnosis and prognosis. Detection of genetic alternation is one of the most important tests for cancer patient since they offen correlated with the clinical course, prognosis and chemosensitivity of primary brain tumors. Currently in brain tumor patients these molecular aberrations can be analyzed only on tumor tissue that was obtained at surgery or biopsy. Paucity of pathologic samples or poor fixation technique often make the tissue samples unassessable for molecular aberrations. Therefore, the ability to extract tumor DNA from peripheral blood holds a great clinical significance. Still, the molecular aberration evaluated on serum DNA should be correlated and verified by comparison to standard evaluations performed on tumor samples. Our study aim is to evaluate the feasibility of using serum DNA for routine diagnosis of tumor molecular aberrations.
["Israel"]
Not yet recruiting
November 2005
NCT00265174
Serum DNA Analysis: Potential Application for Diagnosis and Prognosis in Brain Cancer.
Serum DNA Analysis: Potential Application for Diagnosis and Prognosis in Brain Cancer.
IRISL1-HMO-CTIL
["SERUM DNA", "LOH", "METHYLATION", "GLIOMA", "MGMT"]
ClinicalTrials.gov processed this data on October 13, 2015
{"last_name": "ARIK TZUKERT, DMD", "phone": "00-972-2-6776095", "email": "ARIK@HADASSAH.ORG.IL"}
{"last_name": "HADAS LAMBERG, PHD", "phone": "00-972-2-6777572", "email": "LHADAS@HADASSAH.ORG.IL"}
60
University of Ottawa
No
Interventional
Traditional harvesting of the internal thoracic artery (ITA) for use as a conduit in coronary bypass surgery involves the dissection of a rim of tissue surrounding the artery on either side. Although the benefits of ITA use are well established, there are certain limitations to its routine use. Recent studies, primarily observational, have suggested that skeletonization of the ITA (i.e. harvesting of the ITA alone) may overcome some of these limitations by improving conduit flow, increasing length, and reducing the risk of deep sternal infection in high risk patients. Furthermore, skeletonization of the ITA can potentially preserve intercostal nerves and reduce post-operative pain and dysesthesias associated with ITA harvesting. In order to assess the effects of ITA skeletonization, this is a prospective, randomized, within-patient study design in patients undergoing coronary artery bypass grafting.
December 13, 2005
[{"last_name": "Fraser D. Rubens, MD", "role": "Principal Investigator", "affiliation": "University of Ottawa Heart Institute, Division of Cardiac Surgery"}]
December 13, 2005
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double-Blind, Primary Purpose: Treatment
N/A
[{"lead_sponsor": {"agency": "University of Ottawa", "agency_class": "Other"}}]
{"criteria": {"textblock": "Inclusion Criteria:\n\n - Patients undergoing bilateral internal thoracic artery harvest for coronary artery\n bypass surgery\n\n Exclusion Criteria:\n\n - Inability to speak English or French\n\n - Inability to complete follow-up visits"}, "gender": "Both", "minimum_age": "18 Years", "maximum_age": "N/A", "healthy_volunteers": "No"}
Link to the current ClinicalTrials.gov record.
[{"facility": {"name": "University of Ottawa Heart Institute", "address": {"city": "Ottawa", "state": "Ontario", "zip": "K1Y 4W7", "country": "Canada"}}}]
{"authority": "Canada: Ethics Review Committee"}
["Coronary Artery Disease"]
The purpose of this study is to determine whether skeletonization of the internal thoracic artery leads to improved flow, increased length, improved sternal perfusion, and decreased pain and dysesthesia in patients undergoing coronary artery bypass surgery
["Canada"]
Completed
November 2005
NCT00265499
[{"intervention_type": "Procedure", "intervention_name": "Skeletonization of the internal thoracic artery"}]
[{"measure": "Intra-operative Internal Thoracic Artery Flow measure prior to coronary anastomoses"}]
The Internal Thoracic Artery Skeletonization Study: A Paired, Within-Patient Comparison
Skeletonized Versus Non-Skeletonized Internal Thoracic Artery Harvest for Coronary Artery Bypass Grafting
R03-41
["Coronary Artery Bypass", "Skeletonization", "Internal Thoracic Artery", "Flow", "Length", "Pain"]
ClinicalTrials.gov processed this data on October 13, 2015
{"mesh_term": ["Coronary Artery Disease", "Coronary Disease", "Myocardial Ischemia"]}
[{"measure": "- Internal Thoracic Artery length"}, {"measure": "- Sternal Perfusion (SPECT imaging)"}, {"measure": "- Post-operative pain and dysesthesia"}]
Inje University
No
Interventional
December 14, 2005
[{"last_name": "Young Jin Yuh, M.D.", "role": "Principal Investigator"}]
December 14, 2005
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Phase 3
[{"lead_sponsor": {"agency": "Inje University", "agency_class": "Other"}}]
{"criteria": {"textblock": "Inclusion Criteria:\n\n - Patients with pathologically confirmed, advanced(clinical stage IIIB or IV) NSCLC\n\n - No previous chemotherapy history\n\n - Age \u2265 65 years\n\n - ECOG performance status \u2264 2\n\n - Adequate marrow function (ANC \u2265 2,000/mm3, platelet \u2265 100,000/mm3), renal and liver\n function (total bilirubin < 2.0 mg/dL, AST/ALT levels < 3 \u00d7 the upper limit of\n normal, serum creatinine < 2.0 mg/dL)\n\n - Patients with informed written consent\n\n Exclusion Criteria:\n\n - Patients with other major illness(active infection, severe heart disease, concomitant\n malignancy, etc)"}, "gender": "Both", "minimum_age": "65 Years", "maximum_age": "N/A", "healthy_volunteers": "No"}
Link to the current ClinicalTrials.gov record.
[{"facility": {"name": "Inje University Sanggyepaik Hospital", "address": {"city": "Seoul", "zip": "139-707", "country": "Korea, Republic of"}}, "status": "Recruiting", "contact": {"last_name": "Young Jin Yuh, M.D.", "phone": "82-2-950-1460", "email": "yjyuh@sanggyepaik.ac.kr"}, "investigator": {"last_name": "Young Jin Yuh, M.D.", "role": "Principal Investigator"}}]
{"authority": "Korea: Food and Drug Administration"}
["Non-Small Cell Lung Cancer"]
1. Recently a radomized trial of vinorelbine versus best supportive care in patients at 70 years of age or older demonstrated a definite improvement in overall survival rate and quality of life with chemotherapy. 2. The role of combination therapy containing the platinum compound, which is the standard therapy for the young patients is still vague. 3. Gemcitabine and carboplatin have favorable toxicity profile.
["Korea, Republic of"]
Recruiting
June 2005
NCT00265694
[{"intervention_type": "Drug", "intervention_name": "vinorelbine, gemcitabine and carboplatin"}]
Random Trial for Elderly Patients With NSCLC
A Randomized Phase III Trial of Vinorelbine Versus Gemcitabine and Carboplatin for Elderly Patients With Advanced Non-Small Cell Lung Cancer
INJE05-06
ClinicalTrials.gov processed this data on October 13, 2015
{"mesh_term": "Carcinoma, Non-Small-Cell Lung"}
{"mesh_term": ["Carboplatin", "Gemcitabine", "Vinorelbine"]}
{"last_name": "Young Jin Yuh, M.D.", "phone": "82-2-950-1460", "email": "yjyuh@sanggyepaik.ac.kr"}
Hôpital Necker-Enfants Malades
No
Interventional
The precise and exact cause of Crohn’s disease (CD) remains still unknown. However, recent data point out to an inappropriate and exaggerated inflammatory response of the intestinal mucosal immune system toward intestinal commensal flora as initial trigger. Several strategies were developed in the treatment of active CD. Anti-inflammatory drugs such as steroids proved to be very helpful in the induction of a primary remission as is the use of exclusive enteral nutrition. Besides a long standing experience with EN in the management of CD in several centres, the mode of action and the molecular mechanisms of a specific EN, such as Modulen IBD ® remain still unknown. The ultimate aim of this study is to compare the efficacy of Modulen IBD ® in inducing remission compared to steroids with a detailed analysis of the mucosal repair and anti-bacterial defence mechanisms within the inflamed intestinal mucosa and the composition of the commensal flora before and during therapy. This approach may help to elucidate the interaction between the intestinal mucosa and the commensal flora during the onset of CD and induction of remission.
December 14, 2005
[{"last_name": "Frank M Ruemmele, MD PhD", "role": "Principal Investigator", "affiliation": "H\u00f4pital Necker Enfants Malades, Assistance Publique-H\u00f4pitaux de Paris, Service de Gastroenterologie p\u00e9diatrique, INSERM EMI0212, Paris, France"}]
December 14, 2005
November 2005
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Phase 4
[{"lead_sponsor": {"agency": "H\u00f4pital Necker-Enfants Malades", "agency_class": "Other"}}, {"collaborator": {"agency": "Institut National de la Sant\u00e9 Et de la Recherche M\u00e9dicale, France", "agency_class": "Other"}}, {"collaborator": {"agency": "Nestl\u00e9", "agency_class": "Industry"}}]
{"criteria": {"textblock": "Inclusion Criteria:\n\n Crohn's disease active disease small bowel involvement\n\n Exclusion Criteria:\n\n antibiotic therapy within 4 weeks prior to inclusion immunosuppressive therapy within 4\n weeks prior to inclusion not willing to collaborate isolated oral or perianal involvement"}, "gender": "Both", "minimum_age": "6 Years", "maximum_age": "18 Years", "healthy_volunteers": "No"}
Link to the current ClinicalTrials.gov record.
[{"facility": {"name": "H\u00f4pital Necker Enfants Malades, Facult\u00e9 de M\u00e9decine Necker, INSERM EMI0212", "address": {"city": "Paris", "zip": "F-75015", "country": "France"}}, "status": "Recruiting", "contact": {"last_name": "Frank M Ruemmele, MD PhD", "phone": "33.1.44.49.44.12", "email": "frank.ruemmele@nck.ap-hop-paris.fr"}}]
{"authority": "France: Afssaps - Agence fran\u00e7aise de s\u00e9curit\u00e9 sanitaire des produits de sant\u00e9 (Saint-Denis)"}
["Crohn's Disease", "Pediatric"]
The primary purpose of this study is to compare the efficacy of enteral nutrition compared to steroids in inducing remission of active pediatric Crohn’s disease. The main hypothesis of this study is that the use of enteral nutrition induces mucosal healing, whereas steroids do not. This effect may be related to a change of the commensal flora during enteral nutrition.
["France"]
Recruiting
November 2005
NCT00265772
[{"intervention_type": "Drug", "intervention_name": "MODULEN IBD (R) (specific Enteral Nutrition)"}, {"intervention_type": "Drug", "intervention_name": "prednisolon"}]
[{"measure": "Mucosal Healing (decrease >70% of the Crohn's disease endoscopic index score after 8 weeks of treatment)"}]
Comparison of a Nutritional Anti-Inflammatory Treatment to Steroids for Pediatric Crohn's Disease - the Molecular Basis
Phase IV Study Comparing a Nutritional Anti-Inflammatory Treatment to Steroids for Pediatric Crohn's Disease - the Molecular Basis
NCNF0105
["enteral nutrition", "steroids", "mucosal healing"]
ClinicalTrials.gov processed this data on October 13, 2015
{"mesh_term": "Crohn Disease"}
[{"measure": "clinical remission (Harvey Bradshaw Index <5)"}, {"measure": "biological remission (decrease of systemic and mucosal inflammatory markers)"}, {"measure": "improvement of the anti-bacterial defense"}]
{"mesh_term": "Anti-Inflammatory Agents"}
{"last_name": "Frank M Ruemmele, MD PhD", "phone": "33.1.44.49.44.12", "email": "frank.ruemmele@nck.ap-hop-paris.fr"}
{"last_name": "Laurence Beck, PhD", "phone": "33.1.60.53.41.52", "email": "laurence.beck@fr.nestle.com"}
[{"citation": "Bannerjee K, Camacho-H\u00fcbner C, Babinska K, Dryhurst KM, Edwards R, Savage MO, Sanderson IR, Croft NM. Anti-inflammatory and growth-stimulating effects precede nutritional restitution during enteral feeding in Crohn disease. J Pediatr Gastroenterol Nutr. 2004 Mar;38(3):270-5.", "PMID": "15076624"}, {"citation": "Heuschkel RB, Menache CC, Megerian JT, Baird AE. Enteral nutrition and corticosteroids in the treatment of acute Crohn's disease in children. J Pediatr Gastroenterol Nutr. 2000 Jul;31(1):8-15.", "PMID": "10896064"}, {"citation": "Heuschkel RB, MacDonald TT, Monteleone G, Bajaj-Elliott M, Smith JA, Pender SL. Imbalance of stromelysin-1 and TIMP-1 in the mucosal lesions of children with inflammatory bowel disease. Gut. 2000 Jul;47(1):57-62.", "PMID": "10861265"}, {"citation": "Belli DC, Seidman E, Bouthillier L, Weber AM, Roy CC, Pletincx M, Beaulieu M, Morin CL. Chronic intermittent elemental diet improves growth failure in children with Crohn's disease. Gastroenterology. 1988 Mar;94(3):603-10.", "PMID": "3123302"}, {"citation": "Ruemmele FM, Roy CC, Levy E, Seidman EG. Nutrition as primary therapy in pediatric Crohn's disease: fact or fantasy? J Pediatr. 2000 Mar;136(3):285-91. Review.", "PMID": "10700682"}, {"citation": "Gailhoustet L, Goulet O, Cachin N, Schmitz J. [Study of psychological repercussions of 2 modes of treatment of adolescents with Crohn's disease]. Arch Pediatr. 2002 Feb;9(2):110-6. French.", "PMID": "11915490"}]

Statistics

Average successful run time: about 5 hours

Total run time: 2 months

Total cpu time used: about 20 hours

Total disk space used: 2.45 GB

History

  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
    22 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
    2 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
    2 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
    11 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
    1 page scraped
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    3752 records added, 3752 records removed in the database
  • Auto ran revision 111c5256 and completed successfully .
    1228 records added, 1228 records removed in the database
  • Auto ran revision 111c5256 and completed successfully .
    260 records added, 260 records removed in the database
  • Auto ran revision 111c5256 and completed successfully .
    1278 records added, 1278 records removed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
    nothing changed in the database
  • Auto ran revision 111c5256 and completed successfully .
  • Auto ran revision 111c5256 and completed successfully .
  • Auto ran revision 111c5256 and completed successfully .
  • Auto ran revision 111c5256 and completed successfully .
    496 records added, 496 records removed in the database
  • Auto ran revision 111c5256 and completed successfully .
    3891 records added, 3891 records removed in the database
  • Auto ran revision 111c5256 and completed successfully .
    4554 records added, 4554 records removed in the database
  • Auto ran revision 111c5256 and completed successfully .
    325 records added, 325 records removed in the database
  • Auto ran revision 111c5256 and completed successfully .
    881 records added, 881 records removed in the database
  • Auto ran revision 111c5256 and completed successfully .
    1588 records added, 1588 records removed in the database
  • Auto ran revision 111c5256 and completed successfully .
    911 records added, 911 records removed in the database
  • Auto ran revision 111c5256 and failed .
  • Auto ran revision 111c5256 and completed successfully .
  • Auto ran revision 111c5256 and completed successfully .
    832 records added, 832 records removed in the database
    939 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    2087 records added, 2087 records removed in the database
  • Auto ran revision 111c5256 and completed successfully .
    23342 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    3121 records added, 3121 records removed in the database
    3346 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    376 records added, 376 records removed in the database
    24183 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    2382 records added, 2382 records removed in the database
    62332 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    205747 records added in the database
    9752 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    31937 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    6632 records added, 6632 records removed, 16381 records updated in the database
    17299 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    45956 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    23098 records added, 23098 records removed in the database
    24255 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    23468 records added, 23468 records removed in the database
    24651 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    17707 records added, 17707 records removed in the database
    18626 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    870 records added, 870 records removed in the database
    944 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    8175 records added, 8175 records removed in the database
    33621 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    2874 records added, 2874 records removed in the database
    3049 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    24340 records added, 24340 records removed in the database
    51118 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    13953 records added, 13953 records removed in the database
    14699 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    7334 records added, 7334 records removed in the database
    7727 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    1772 records added, 1772 records removed in the database
    1892 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    24638 records added, 24638 records removed in the database
    25872 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    3048 records added, 3048 records removed in the database
    29108 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    24962 records added, 24962 records removed in the database
    26214 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    1485 records added, 1485 records removed in the database
    1579 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    4015 records added, 4015 records removed in the database
    4254 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    26693 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    25485 records added, 25485 records removed in the database
    26795 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    1306 records added, 1306 records removed in the database
    1406 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    651 records added, 651 records removed in the database
    746 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    25686 records added, 25686 records removed in the database
    26973 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    2252 records added, 2252 records removed in the database
    2401 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    26088 records added, 26088 records removed in the database
    27399 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    1808 records added, 1808 records removed in the database
    1975 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    3287 records added, 3287 records removed in the database
    3643 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    28027 records added, 28027 records removed in the database
    29431 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    8280 records added, 8280 records removed in the database
    8715 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    28113 records added, 28113 records removed in the database
    29524 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    28116 records added, 28116 records removed in the database
    29625 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    28208 records added, 28208 records removed in the database
    29621 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    14355 records added, 14355 records removed in the database
    15100 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    2831 records added, 2831 records removed in the database
    2995 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    61315 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    16994 records added, 16994 records removed in the database
    17867 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    30037 records added, 30037 records removed in the database
    31541 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    30444 records added, 30444 records removed in the database
    31969 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    3715 records added, 3715 records removed in the database
    3934 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    7125 records added, 7125 records removed in the database
    7546 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    30960 records added, 30946 records removed in the database
    32510 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    14508 records added, 14424 records removed in the database
    15270 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    4080 records added, 3721 records removed in the database
    4318 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    244 records added, 244 records removed in the database
    290 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    30080 records added, 30016 records removed in the database
    31621 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    1440 records added, 1374 records removed in the database
    1582 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    29503 records added, 29381 records removed in the database
    31307 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    31022 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    668 records added, 446 records removed in the database
    738 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    27943 records added, 27827 records removed in the database
    29345 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    877 records added, 722 records removed in the database
    967 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    11116 records added, 11116 records removed in the database
    13163 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    585 records added, 585 records removed in the database
    1647 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    26590 records added, 26461 records removed in the database
    27922 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    2670 records added, 2670 records removed in the database
    2851 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    1551 records added, 1353 records removed in the database
    1654 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    3229 records added, 3135 records removed in the database
    3442 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    491 records added, 491 records removed in the database
    964 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    289 records added, 289 records removed in the database
    377 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    10011 records added, 9870 records removed in the database
    10559 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    7281 records added, 7281 records removed in the database
    7680 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    461 records added, 454 records removed in the database
    498 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    755 records added, 536 records removed in the database
    939 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    1107 records added, 993 records removed in the database
    1229 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    2306 records added, 2235 records removed in the database
    2465 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    7094 records added, 6718 records removed in the database
    7453 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    19159 records added, 18932 records removed in the database
    20119 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    13538 records added, 13433 records removed in the database
    14262 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    14814 records added, 14714 records removed in the database
    15597 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    1587 records added, 1587 records removed in the database
    1684 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    2693 records added, 2611 records removed in the database
    8338 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    2010 records added, 1998 records removed in the database
    2324 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    122 records added, 33 records removed in the database
    144 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    1323 records added, 1323 records removed in the database
    1428 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    15380 records added, 15252 records removed in the database
    16191 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    9523 records added, 9523 records removed in the database
    10020 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    1493 records added, 1325 records removed in the database
    1578 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    168 records added, 168 records removed in the database
    201 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    4618 records added, 4618 records removed in the database
    4884 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    14927 records added, 14925 records removed in the database
    15676 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    3450 records added, 2839 records removed in the database
    3666 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    2146 records added, 2146 records removed, 613 records updated in the database
    2993 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    17920 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    11906 records added, 11792 records removed in the database
    12493 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    510 records added, 436 records removed in the database
    578 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    4837 records added, 4837 records removed in the database
    5112 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    10044 records added, 10044 records removed in the database
    10549 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    753 records added, 753 records removed in the database
    828 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    10044 records added, 9951 records removed in the database
    10549 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    9601 records added, 9481 records removed in the database
    10084 pages scraped
  • Auto ran revision 111c5256 and completed successfully .
    9090 records added, 9090 records removed in the database
    89779 pages scraped
  • Manually ran revision 111c5256 and completed successfully .
    7772 records added, 7772 records removed in the database
    66034 pages scraped
  • Manually ran revision 111c5256 and completed successfully .
    26521 records added in the database
    55559 pages scraped
  • Manually ran revision 111c5256 and completed successfully .
    23645 records added in the database
    24830 pages scraped
  • Manually ran revision 111c5256 and completed successfully .
    15139 records added in the database
    15898 pages scraped
  • Manually ran revision 111c5256 and completed successfully .
    34160 records added in the database
    35871 pages scraped
  • Manually ran revision 111c5256 and completed successfully .
    24443 records added in the database
    25668 pages scraped
  • Manually ran revision 111c5256 and completed successfully .
    20179 records added, 49180 records updated in the database
    21201 pages scraped
  • Manually ran revision 111c5256 and completed successfully .
    14215 records added in the database
    14939 pages scraped
  • Manually ran revision 111c5256 and completed successfully .
    9844 records added in the database
    10344 pages scraped
  • Manually ran revision 111c5256 and completed successfully .
    8502 records added in the database
    8932 pages scraped
  • Manually ran revision 111c5256 and completed successfully .
    7355 records added, 9264 records updated in the database
    7727 pages scraped
  • Manually ran revision 111c5256 and completed successfully .
    4164 records added, 5100 records updated in the database
    4375 pages scraped
  • Manually ran revision 111c5256 and completed successfully .
    2331 records added in the database
    2450 pages scraped
  • Manually ran revision 111c5256 and completed successfully .
    2769 records added in the database
    2912 pages scraped
  • Manually ran revision 1c2744ef and completed successfully .
    2769 records added in the database
    2910 pages scraped
  • Manually ran revision 08d58973 and completed successfully .
    68 records added, 68 records removed in the database
    74 pages scraped
  • Manually ran revision 0f14f8e4 and completed successfully .
    68 records added in the database
    74 pages scraped
  • Manually ran revision 0f14f8e4 and completed successfully .
    68 records added, 68 records removed in the database
    74 pages scraped
  • Manually ran revision 2fe6089b and completed successfully .
    68 records added, 68 records removed in the database
    74 pages scraped
  • Manually ran revision 1bcb403f and completed successfully .
    68 records added, 68 records removed in the database
    74 pages scraped
  • Manually ran revision c9d9cae3 and completed successfully .
    68 records added, 68 records removed in the database
    74 pages scraped
  • Auto ran revision 3fe50041 and completed successfully .
    68 records added, 68 records removed in the database
    74 pages scraped
  • Auto ran revision 3fe50041 and completed successfully .
    68 records added in the database
    74 pages scraped
  • Auto ran revision c1e6297b and completed successfully .
    nothing changed in the database
  • Auto ran revision c1e6297b and completed successfully .
    nothing changed in the database
  • Auto ran revision c1e6297b and completed successfully .
    nothing changed in the database
  • Auto ran revision c1e6297b and completed successfully .
    nothing changed in the database
  • Manually ran revision df6249b5 and completed successfully .
    nothing changed in the database
  • Auto ran revision dc539795 and completed successfully .
    nothing changed in the database
  • Auto ran revision e10fd2bd and completed successfully .
    nothing changed in the database
  • Auto ran revision e10fd2bd and completed successfully .
    nothing changed in the database
  • Auto ran revision e10fd2bd and completed successfully .
    nothing changed in the database
  • Auto ran revision e10fd2bd and completed successfully .
    nothing changed in the database
  • Auto ran revision e10fd2bd and completed successfully .
    nothing changed in the database
  • Auto ran revision e10fd2bd and completed successfully .
    nothing changed in the database
  • Auto ran revision e10fd2bd and completed successfully .
    nothing changed in the database
  • Auto ran revision e10fd2bd and completed successfully .
    nothing changed in the database
    19 pages scraped
  • Auto ran revision e10fd2bd and completed successfully .
    nothing changed in the database
  • Created on morph.io